Calcitonin Gene-Related Peptide (CGRP) Mechanisms by Susan D. Brain & Pierangelo Geppetti

Author:Susan D. Brain & Pierangelo Geppetti
Language: eng
Format: epub
ISBN: 9783030214548
Publisher: Springer International Publishing

3.6 Intrathecal CGRP Delivery

Studies showed that CGRP is located in small diameter dorsal root ganglion neurons (Hokfelt et al. 1992), dorsal horns (Hokfelt et al. 1992; Ishida-Yamamoto and Tohyama 1989), and intermediolateral and ventral horns of the spinal cord (Bennett et al. 2000; Marti et al. 1987; Senba and Tohyama 1988). Spinal cord central sensitization following intradermal capsaicin injection has been shown to be mediated by CGRP and its receptors (Carlton et al. 1990; Sun et al. 2004). Thus, researchers explored the effects of intrathecal (i.t.) CGRP administration on pain responses (Table 1). Administration of i.t. CGRP induced mechanical and thermal hyperalgesia in rats (Mogil et al. 2005; Oku et al. 1987). Our team showed that a low dose of CGRP injected into the lumbar spinal region did not exacerbate the response to an innocuous mechanical stimulus (von Frey filaments), while a higher dose evoked mechanical allodynia (Marquez de Prado et al. 2009). These data indicate that CGRP can act centrally to sensitize mice to thermal and mechanical stimuli.

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